Epithelial-mesenchymal transition: the history of the concept, debatable issues

The paper discusses diverse aspects of the concept epithelial-mesenchymal transition and compares basics this with classical concepts tissue biology. idea was first suggested by Elizabeth Hay (1927–2007) in 1968 based on analysis tridermogenesis development growth avian embryo. In late 80 s – early 90 twentieth century, epithelial–mesenchymal won supporters-pathomorphologists our country who applied to explain mechanisms multiple pathological processes. controversial issue arises: which extent is validated. It should be noted that a number its basic principles are open question. Thus, it hardly correct consider cells ectoderma as epithelial cells, since they do not express immunohistochemical markers cells. That is, true phenotype yet represented at stage embryogenesis. also taken into account all evidence for indirect immunocytochemical findings (decreased expression markers, increased mesenchymal genesis). Moreover, saying about “epithelial-mesenchymal transition” specialists mean cell populations specific same. All above allows arguing existence transition; needs additional research more fact-based support.